We'll be leaving Fredericksburg (western Spotsy County) so a 64 west solution would be best. I know the best route to 64 so picking it from there...
the best way:
64 west to 81
81 north toward Stanton to second exit (~3 mi)
. (Woodrow Wilson Park Way/ 250 by pass.) Take this exit to Rt 250 to Monterey
Follow 250 to Monterey (apro 1 hour travel time over 4/5 ridges. Some of these switch back can catch you off guard so stay focused on the road. Heed the the 3ft black arrows. particularly the first just after you enter Geo. Wast. Nat, Forest
Take left on to RT 220 at light (only light) in Monterey.Intersection of 250 and 220 BP station good place to fuel
Follow aprox 4
miles. ( 1 hour from Monterey to Snowshoe)
Right on Rt 84 to Frost. Aprox 18
At Frost right turn on to RT 92 at the Y
toward Dunmore/Cass. Follow to Rt 66. (you will see a SnowShoe sign at intersection)
Left on 66 to Cass. ( aprox 8 miles to Cass) Cross over river and continue on 66 to Snowshoe. You will make a 6/7 mile climb.Snowshoe access rd entrance on the right.
Any advice will be greatly appreciated.
Made this trip a couple of times from Richmond area the past 2 weeks. It's the fastest/easiest 3.5hrs from 288/64 intersect. From Staunton on it goes pretty quickly. 250 is good road, just stay on your toes. From Monteray it is 1 hour and the drive is beautiful, mostly all flat valley until just before Cass.
From Cass on, watch out for the Bloated Suv's with Napoleonic complex drivers cutting the corners short or trying to intimidate you, just
and give'm the peace sign.
 older gentleman at BP station(somewhat local)handed me these printed directions and assured me it was the best way.